13th World Conference on Neurology and Neuromuscular Disorders October 01-02, 2018 Frankfurt, Germany

Epilepsy is a chronic disorder of the brain that affects people worldwide. It is characterized by recurrent seizures, which are brief episodes of involuntary movement that may involve a part of the body (partial) or the entire body (generalized), and is sometimes accompanied by loss of consciousness and control of bowel or bladder function. Approximately 50 million people worldwide suffer from epilepsy, now epilepsy becomes the most common neurological diseases globally. Nearly 80 percent people middle income countries who lives with epilepsy and do not get treatment they need. Peoples with epilepsy suffer discrimination in many parts of the world. Epilepsy results in an estimated annual cost of $15.5 billion.

The global epilepsy drug market is expected to grow at CAGR of 5% in the second half of the forecast period. In 2016, the global Epilepsy drug market is $4.3bn and is expected to grow at $6.9bn in 2027.

Epilepsy is one of the most common neurological disorders globally that affect approximately 50 million peoples worldwide.

On estimation 2.4 million peoples are diagnosed with epilepsy each year. Almost 80% peoples suffer from epilepsy lived in low and middle income countries.

The most common type of epilepsy is Idiopathic epilepsy which has no identifiable cause which affects 6 out of 10 people.

Cellular neuroscience is the investigation of neurons at a cell level. This incorporates morphology and physiological properties of single neurons. A few strategies, for example, intracellular recording, fix cinch, and voltage-brace method, pharmacology, confocal imaging, sub-atomic science, two photon laser checking microscopy and Ca2+ imaging have been utilized to study movement at the cell level. Cell neuroscience looks at the different sorts of neurons, the elements of various neurons, and the impact of neurons upon each other, how neurons cooperate.

Sub session in this track:

• Behavioural Neuroscience
• Neuroglial Cells
• Synaptic activities
• Neurotransmitters

Parkinson’s sickness is a dynamic issue of the sensory system that influences development. It grows slowly, in some cases beginning with a scarcely detectable tremor in only one hand. However, while a tremor might be the most surely understood indication of Parkinson's infection, the turmoil likewise regularly causes solidness or moderating of development. In the early phases of Parkinson's illness, your face may indicate next to zero demeanours, or your arms may not swing when you walk. Your discourse may turn out to be delicate or slurred. Parkinson's malady indications compound as your condition advances after some time.

Sub sessions of the Parkinson’s Diseases:

• Neorocognitive Disorders
• Pathophysiology and Pharmacology
• Managing life with Parkinson’s disease

According to the WHO, the number of people with disability-adjusted life year due to Parkinson’s disease was 1.7 million globally in 2015.

According to European Parkinson’s Disease Association, the cost of treatment for this disease in Europe was estimated at US$ 12.6 Million in 2005 and is expected to double by 2030.

As per the European Brain Council around 6.3 million people suffer from Parkinson’s disease.

Parkinson incident rates increase with aging and the percentage of the world’s population above the age of 65 years will increase from 7% to 16% from 2000-2050 will serve this market as a driver.

The underlying assessment of a patient with a recently analysed tumour of the sensory system is a basic stride toward proper administration and patient care. The most critical segments of the underlying assessment are an itemized history and an exhaustive examination. This procedure serves to distinguish the degree and nature of neurological shortfall, gives indicative insights, can help unveil a wellspring of metastasis, or may recognize a hereditary procedure connected with an essential focal sensory system tumour.
There is no doubt that the clinical administration of neuro-oncology patients is testing. In any case, on the off chance that we are to help patients and eventually make propels in treating these tumours, fastidious and humane care of patients with neurological malignancies are pivotal.
Lumbar cut (LP) and cerebrospinal fluid (CSF) examination are essential for the assessment of some essential tumours, metastatic conditions, and neurologic complexities of growth

Sub Sessions in Neuro-oncology are:

• Psycho Oncology
• Radiation therapy
• Neuropharmacology of cancer
• Inoperable brain tumor
• Brain tumor
   

According to the reports, the radiation Oncology market size is expected to reach USD 10.1 billion by 2025.

Dementia is a decline in mental ability severe enough to interfere with day to day life. The most commonly occurring symptoms of dementia are decrease in ability to think and remember, emotional problems, problems with language, decrease in motivation. World Health Organisation’s list of top ten leading causes of deaths all over the world, Alzheimer’s and other dementias has 7^th ranking. Dementia has overtaken as leading cause of death in England and Wales over heart diseases. Alzheimer’s is one of the major causes of death in the USA and it kills more than breast and prostate cancer combined. To solve problems of globally various dementia conferences were arranged to find cure for dementia society universally.

Sub sessions of the dementia are:

• Vascular Dementia
• Traumatic brain injury
• Diagnosis and Symptoms
• Imaging Techniques
• Geriatrics and Cognitive Disorder

According to Research and Markets report, the global dementia and movement disorder treatment market to grow at a CAGR of 4.48% during the period 2017-2021.

On estimation, 850, 000 people are living with dementia in the UK.

Globally, the people suffer from Dementia will increase from 46.8m in 2015 to 131.5m in 2050, a 281% increase

It is the harm to the spinal cord that causes changes in its capacity, either transitory or lasting. These progressions convert into loss of muscle capacity, sensation, or autonomic capacity in parts of the body served by the spinal line beneath the level of the sore. Wounds can happen at any level of the spinal rope and can be named finished harm, an aggregate loss of sensation and muscle work, or inadequate, which means some apprehensive signs can go past the harmed range of the string.

Some of the major Spinal Injuries are:

• Scoliosis
• Kyphosis
• Osteoporosis
• Duchenne Muscular Dystrophy

Spinal cord injuries affect over 40K people in the UK and around 270,000 in the US.
There are 12K new cases of spinal cord injury in the US each year.
According to a report, Global Slip Disc markets grow at the CAGR of ~5.4% during the forecast period and are expected to reach USD 11,011.3 million by 2023.

Brain issues happens when Brain is harmed by Brain damage, illness, or wellbeing conditions. The three Brain chemicals noradrenaline, dopamine and serotonin are included in both real capacities and Brain.

There are 10 million individuals in the UK living with a neurological condition which significantly affects their lives. Basically stroke, dementia, cerebral pain, Brain damage and epilepsy are the neurological conditions endured in UK. It has been evaluated that the lifetime danger of creating Brain and other focal sensory system malignancy is 1 in 133 for men and 1 in 185 for ladies in the UK.

The objective of this session is to comprehend the Causes, Origin, Genesis and Source of different sorts of Brain issues. The reasons for Brain issues: Brain injury, Stroke, Viral contaminations, Tumour, Brain's electrical pathway and Genesis of Brain.
 

Some of the major brain disorders are:

• Brain Stroke
• Autism and Schizophrenia
• Neuropharmacology and Therapeutics
• Therapies for genetic disorders

The global brain monitoring devices market is expected to grow at a CAGR of 6.5% and 7.0% during the forecasting period 2017-2023 and is expected to touch the figure of $10,011.5 million by 2023.

Autonomic and Central issue may come about because of different issue that harm autonomic nerves or they may happen all alone. Dynamic autonomic disappointment normally gets to be evident in the 6th decade of life. The Working of the focal sensory system has turned out to be increasingly broad and more crucial as examination has progressed in analysing it. CNS issue can be either myelopathy or encephalopathy.

Some of the tracks include in CNS Disorders:

• Bipolar Disorder
• Neuropathic pain syndromes
•  Accessory nerve disorder
• CNS disorder and structural defects

According to a report Central Nervous System (CNS) Disorders Therapeutics Market to grow at 5.59% CAGR during the period 2016-2020. And, is expected to reach $128.9 Billion.

Global mental health therapeutics revenue accounted for 48% share in 2016 and is expected to grow at a significant rate from 2016 to 2025.

It expands the reviews on the sensory system and the endocrine framework which mirrors the reviews on hormonal reactions at the ganglions and their sources in cerebrospinal liquids pituitary organs.
It utilizes a Wide scope of neuroscience systems extending from sub-atomic science and hereditarily controlled rat models to electrophysiological, ontogenetic, morphological, cell imaging and entire creature ways to deal with get the certainties how the mind fortifying hormone levels and how hormones accordingly control cerebrum work.

Some of the track include in Neuro Endocrinology:

• Neuro Endocrine cells
• Hypothalamus
• Neurohypophysis
• Adrenal glands

The global Huntington’s disease therapeutics market to grow at a CAGR of 14.75% during the period 2017-2021

Neurodegeneration or neuron demise is the dynamic loss of structure or capacity of neurons which incorporates disarranges like Alzheimer's illness, Parkinson's malady and so on. In the United States, close around 60,000 instances of Parkinson's illness are analysed every year. The third driving reason for death after tumour and coronary illness is Stroke, along these lines concentrating on the study of disease transmission of stroke and hazard factors. Stroke can be of various sorts.

Some of major neurodegenerative disorders are:

• Haemorrhage stroke and ischemic stroke
• Amyotrophic lateral sclerosis (ALS)
• Imaging, diagnosis and acute stroke management

The global Central Nervous System (CNS) therapeutic market size was worth USD 77.2 billion in 2016 and is anticipated to grow at a CAGR of 5.9% during the forecast period.

Global multiple sclerosis market is rapidly growing and it is expected to cross US$ 20 Billion by 2022.

Neurodevelopment disorders are the disabilities or the group of disorders associated with the developmental deficits of the central nervous system. It shows up early in child’s development, affecting in many areas of life function and encompasses disorders of language and speech, movement, the special senses, learning, or other neurological functions. The symptoms and behaviours of neurodevelopment disorders changes as a child grows older. While some disorders are permanent. The diagnosis and treatment of these disorders are not know or difficult but medication and therapies with some home base programs are exist for the cure of these disorders.

Some of major neurodevelopment disorders are:

• Attention Deficit Hyperactivity Disorder (ADHD)
• Autism Spectrum Disorders (ASD)
• Cerebral palsy
• Expression disorder
• Impairments in vision and hearing

According to the reports of Persistence Market research ADHD therapeutics market is expected to expand at a CAGR of 6.2% during forecast period 2015 – 2024. The market segmentation based on the drug type, age group, distribution channel and region.

The Lisdexamfetamine Dimesylate drug type sub-segment is expected to grow at highest CAGR of 15.6% in value terms during the forecast period. 

In USA, 11% of children between the age of 4 and 17 and of total 4.4% of adults suffered from the ADHD Diseases.

Qualities influence the wiring and workings of the mind, which is the power of every one of our rides. It is eventually and exclusively the qualities that offer ascent to a specific kind of protein that might be useful or hurtful that mirrors the need of research in this specific field. 6000 and all the more rising hereditary issue represent a noteworthy partition of human sickness and conditions. Almost 4 percent of the around 4 million children conceived every year have a hereditary malady or significant birth imperfection. Around 15,000 Americans are analysed to have Huntington's illness (HD).Keeping the same in view the accompanying sub tracks are intended to illuminate the contemplations identified with Huntington's sickness (HD) and related hereditary issue.

Some of the Neurogenetics disorders are:

• Huntington disease
• Cancer genetics
• Gene defect and diseases
• Biochemical genetics

Neurological diseases give their impact to estimated 100 million Americans every year. The cost of Stroke and Dementia alone expected to figure more than $600 billion by 2030.

According to a report, estimated 5.5 million Americans are living with Alzheimer’s disease in 2017. Two-thirds of Americans with Alzheimer’s are women.

The Alzheimer's disease Therapeutics and Diagnostics Market reached at $6.71bn in the year 2016 and is expected to grow at a CAGR of 15.3% in the 2^nd half of the forecasted period.

Neurosurgery is the speciality concerned with the diagnosis and treatment of patients with injury or diseases of the brain, spinal column, spinal cord and peripheral nerves in all parts of the body. It is a sister discipline to neuromedicine which deals in the diagnosis and treatment of neurological diseases and complications using medications and non-surgical methods.

Some of the types of Neurosurgery are:

• Spine neurosurgery
• Plastic Neurosurgery
• Oncological neurosurgery
• Current neurosurgery methods
• Neuroanaesthesia and surgery
   

Global Neurosurgical Devices Market is expected to grow at a CAGR around 9% during the forecast period.

Nearly 13.46% of the global population suffering from neurological disorders. Some of the most prevalent diseases are Epilepsy, Parkinson’s Diseases, Alzheimer diseases and Neuro-infections. Neurological disorders are the cause behind the 10% of death all over the world.

According to a report Global Neurosurgical Devices Market is expected to grow at a CAGR of 10.5% between the forecast periods of 2017-2023.

Movement Disorders are a group of diseases of neurological conditions that affect the speed, quality, and ease of movement which may be voluntary or involuntary. More than 30 diseases are diagnosed as neurological movement disorders. Movement disorders are often induced by neurotic changes inside the brain. Regularly, the reason may not be known, despite the fact that heredity and environment factors having a role in some cases. The treatment includes medication, occupational and physical therapy and surgical procedures.

Types of Movement Disorders are:

• Ataxia
• Dystonia
• Essential Tremor
• Parkinson's Disease
• Atypical Parkinsonism

According to Epidemiology studies, The Ataxia prevalence is of around 10 per 100,000 populations and idiopathic ataxia likely outnumbers genetic cases.

Dystonia is a disorder of muscles that causes slow abnormal postures of the musculature that are uncontrolled by the patient. According to a report Global cervical dystonia market is expected to grow at a CAGR of 5% during the forecast period of 2017-2023.

Parkinson’s disease is common age related neurodegenerative disorder. An estimated 10 million people suffer from Parkinson's disease and expected to increase every year. A patient suffered from this disease spends around $2500 per year on the medications to aid in ease of life.

Neuromodulation is a treatment for relieving the chronic pain. In this process small doses or weak electrical signals are used to alter the pain signals. This method is a life changing for individuals living with unmanageable chronic pain and/or movement disorders. This process affects all areas of the body were pain lingers.

There is a number of forms for Neuromodulation:

• Spinal Cord Stimulation (SCS)
• Peripheral Nerve Stimulation (PNS)
• Deep Brain Stimulation (DBS)

Neuromodulation is one of the best methods which have the ability to treat pain without relying on medications.
Around 60% patients show improvement in their lifestyle with chronic pain following implantation of peripheral nerve stimulators.
In clinical trials, after getting a treatment with Spinal Cord Stimulation (SCS), approximately 59% patients suffered from chronic pain reported excellent pain relief.
Deep Brain Stimulation (DBS) provides long term improvement in the quality of life to the patients suffering from Parkinson’s disease, essential tremor and dystonia.

Child Neurology is a branch of medicine that deals with the diagnosis of neurological diseases infants, children and adolescents. It encompasses the diseases of PNS, CNS, Spinal Cord, brain and blood vessels that affects an individual in this age group. About 40% to 50% of the patients treated in a typical paediatric neurology practice have epilepsy, while 20% have developmental problems and remaining’s are suffering from headaches and some are treated for unusual conditions such as genetic diseases.

Some of the diseases diagnosed in paediatric neurology are:

• Childhood Epilepsy
• Neurodegenerative and Neurometabolic disorders
• Motor disorders
• Febrile seizures
• Headaches and migraine
• Genetic diseases of the nervous system

According to Global Business Intelligence Research report, the epilepsy therapeutic market value in major countries (US, France, Canada, Germany, Italy, Japan, and Spain) will increase at modest CAGR of 3.9%.

The epilepsy therapeutic market in 2012 is $3.4 billion which extended up to $4.5 billion by 2019.

In case of Epilepsy diseases, North America market is the most mature market, which is expected to reach with an estimated value of over USD 2,500 million by 2024.

Some of the key players in Epilepsy drug market are Sanofi S.A, Abbott Laboratories, Inc., Sunovion Pharmaceuticals, Inc., UCB Pharma Ltd., Johnson & Johnson, Novartis AG etc.

Neuromuscular Disorders is a term that encompasses many diseases and ailments that impairs with the functioning of muscles. It affects the peripheral nervous system, which consists of all the motor and sensory nerves that connect the brain and spinal cord to the rest of the body.  Dynamic muscle weakness is the predominant state of these disorders.

Example of NMD includes:

• Amyotrophic lateral sclerosis
• Multiple sclerosis
• Myasthenia gravis
• Spinal muscular atrophy

Myasthenia Gravis is an autoimmune disease that affects the neuromuscular junction. With a prevalence of 150-250 cases per 1 million, MG and its subgroups are the major disorders that affect neuromuscular junction.

Multiple Sclerosis is an inherited disorder.  According to the estimation of Multiple Sclerosis Foundation, about 2.5 MN people around the world have MS. The ration of men with MS to women with the disease is 1 to 2. Amyotrophic lateral sclerosis is a progressive neurological disorder that affects the function of nerves and muscles. According to an estimation ALS is the cause of five in every 100, 000 deaths in people ages 20 or older

Spinal Muscular Atrophy is a fatal autosomal recessive disorder which affects 1 in 40 people that carries SMA gene. It causes progressive muscle wasting and paralysis. 

Neuroimmunology is the branch that deals with the interaction of immune system with nervous system in the health and diseases such as the effect of autonomic nervous activity on the immune response (as multiple sclerosis). This diseases occurs when immune system “activated” by an infection or vaccine. In that case immune system damages the peripheral nerves, brain or spinal cord.

Some of examples of diseases in this category include:

• Multiple Sclerosis
• Optic neuritis
• Transverse myelitis
• Guillain-Barre Syndrome
• Chronic inflammatory demyelinating polyneuropathy
• Myasthenia Gravis

According to technavio report, the global acute ischemic stroke (AIS) therapeutics markets to grow at a CAGR of more than 2% of during the forecast period.

Global myasthenia gravis drugs market to grow at a CAGR of 13.16% during the forecast period 2017-2021.